As machine learning becomes increasingly central to molecular design, it is vital to ensure the reliability of learnable protein-ligand scoring functions on novel protein targets. While many scoring functions perform well on standard benchmarks, their ability to generalize beyond training data remains a significant challenge. In this work, we evaluate the generalization capability of state-of-the-art scoring functions on dataset splits that simulate evaluation on targets with a limited number of known structures and experimental affinity measurements. Our analysis reveals that the commonly used benchmarks do not reflect the true challenge of generalizing to novel targets. We also investigate whether large-scale self-supervised pretraining can bridge this generalization gap and we provide preliminary evidence of its potential. Furthermore, we probe the efficacy of simple methods that leverage limited test-target data to improve scoring function performance. Our findings underscore the need for more rigorous evaluation protocols and offer practical guidance for designing scoring functions with predictive power extending to novel protein targets.

Developing comprehensive assistive technologies requires the seamless integration of visual and auditory perception. This research evaluates the feasibility of a modular architecture inspired by core functionalities of perceptive systems like 'Smart Eye.' We propose and benchmark three independent sensing modules: a Convolutional Neural Network (CNN) for eye state detection (drowsiness/attention), a deep CNN for facial expression recognition, and a Long Short-Term Memory (LSTM) network for voice-based speaker identification. Utilizing the Eyes Image, FER2013, and customized audio datasets, our models achieved accuracies of 93.0%, 97.8%, and 96.89%, respectively. This study demonstrates that lightweight, domain-specific models can achieve high fidelity on discrete tasks, establishing a validated foundation for future real-time, multimodal integration in resource-constrained assistive devices.

These proceedings include the Late-Breaking Abstracts accepted for the Evo* 2025 Conference, hosted in Trieste (Italy), from April 23th to 25th. These extended abstracts were presented through short talks at the conference, providing an overview of ongoing research and initial results on the application of diverse Evolutionary Computation strategies and other Nature-Inspired methodologies to practical problem domains. Collectively, these contributions point to encouraging directions for future work, underscoring the potential of nature-inspired approaches-- especially Evolutionary Algorithms -- for advancing research and enabling new applications.

A reciprocal recommendation problem is one where the goal of learning is not just to predict a user's preference towards a passive item (e.g., a book), but to

The problem instance size may be large.

We thank all reviewers for the time they invested to review this paper and share their insights. We have conducted experiments on real-world data, yet could not include them within page limits. Publication of the algorithm in an implemented code (e.g. Java as stated in Line 304). The pseudocodes are given below.

A reciprocal recommendation problem is one where the goal of learning is not just to predict a user's preference towards a passive item (e.g., a book), but to

Quantum computing promises a revolution in information processing, with significant potential for machine learning and classification tasks. However, achieving this potential requires overcoming several fundamental challenges. One key limitation arises at the prediction stage, where the intrinsic randomness of quantum model outputs necessitates repeated executions, resulting in substantial overhead. To overcome this, we propose a novel measurement strategy for a variational quantum classifier that allows us to define the unambiguous quantum classifier. This strategy achieves near-deterministic predictions while maintaining competitive classification accuracy in noisy environments, all with significantly fewer quantum circuit executions. Although this approach entails a slight reduction in performance, it represents a favorable trade-off for improved resource efficiency. We further validate our theoretical model with supporting experimental results.

This work addresses the challenge of enabling practitioners without quantum expertise to transition from classical to hybrid quantum-classical machine learning workflows. We propose a three-stage framework: starting with a classical self-training model, then introducing a minimal hybrid quantum variant, and finally applying diagnostic feedback via QMetric to refine the hybrid architecture. In experiments on the Iris dataset, the refined hybrid model improved accuracy from 0.31 in the classical approach to 0.87 in the quantum approach. These results suggest that even modest quantum components, when guided by proper diagnostics, can enhance class separation and representation capacity in hybrid learning, offering a practical pathway for classical machine learning practitioners to leverage quantum-enhanced methods.

Large language model (LLM)-based agents increasingly rely on tool use to complete real-world tasks. While existing works evaluate the LLMs' tool use capability, they largely focus on the final answers yet overlook the detailed tool usage trajectory, i.e., whether tools are selected, parameterized, and ordered correctly. We introduce TRAJECT-Bench, a trajectory-aware benchmark to comprehensively evaluate LLMs' tool use capability through diverse tasks with fine-grained evaluation metrics. TRAJECT-Bench pairs high-fidelity, executable tools across practical domains with tasks grounded in production-style APIs, and synthesizes trajectories that vary in breadth (parallel calls) and depth (interdependent chains). Besides final accuracy, TRAJECT-Bench also reports trajectory-level diagnostics, including tool selection and argument correctness, and dependency/order satisfaction. Analyses reveal failure modes such as similar tool confusion and parameter-blind selection, and scaling behavior with tool diversity and trajectory length where the bottleneck of transiting from short to mid-length trajectories is revealed, offering actionable guidance for LLMs' tool use.